Genetics

Genetics is one of the major themes of UK-PBC. The Genetics study was initiated by Dr Richard Sandford and Dr Graeme Alexander in 2007 and was a UK-wide effort to identify genetic variants associated with PBC.

Several projects have been completed as part of the UK-PBC Genetics Study and several others are ongoing.

Completed Studies

• UK-GWAS of PBC
• UK iCHIP Study of PBC

Ongoing Studies

• International genome-wide meta-analysis of PBC
• International combined GWAS of cholestatic pruritus
• Genome-wide LT-free survival analysis of PBC